Focus and Scope

British Journal of Intensive Care, published by Greycoat Publishing.. collaborates with British Medical Association. are dedicated to providing physicians with the best research and important information in the world of medical research and science and to present the information in a format that is understandable and clinically useful. Committed to publishing multidisciplinary research that spans the entire spectrum of healthcare and medicine access, British Journal of Intensive Care aims at an international audience of pharmacists, clinicians, medical ethicists, regulators, and researchers, providing an online forum for the rapid dissemination of recent research and perspectives in this area.

British Journal of Intensive Care Evidence seeks to advance clinical trial research and clinical practice by:

• Publishing high-quality studies from the front lines of medical research.
• Challenging the medical community to take new approaches to clinical trial design and execution that yield more powerful clinical evidence.
• Sparking debate and conversation around areas of medicine where clinical decisions are made without sufficient evidence.
• Engaging physicians in a more sophisticated and meaningful way with clinical evidence.

Adhering to the rigorous peer-review and quality standards expected from British Journal of Intensive Care Evidence publishes:

• Original research, clinical trials, and other clinically grounded work (e.g., epidemiology studies, first-in-human trials, meta-analyses) that validate or challenge prior clinical findings.
• Standard reviews, systematic reviews, and other review types that contextualize research findings with the aim of accelerating clinical adoption of new evidence.
• Case studies and reviews of clinical trial methodology that enhance understanding of trial strengths and weaknesses.
• Curbside consult series that addresses common patient care issues.
• Morning Report series solicited case presentation articles that are delivered in a morning report format.

Generation of Evidence

The process of generating evidence is a key area of focus for British Journal of Intensive Care Evidence. We encourage readers to evaluate the reasoning behind the complex decisions that investigators make in trial design and execution, and to assess the quality of evidence produced in trials. Our goal is to build a community that takes a rigorous approach to evaluating evidence and assessing its impact on clinical decision-making.

Statistical Methods

British Journal of Intensive Care Evidence guides readers toward a deeper understanding of the statistical methods used in trials. We provide concise, digestible explanations of research methods to inform the interpretation of the resulting data. In addition, we introduce readers to emerging statistical methods and types of data that will play an increasingly prominent role in future trials.

Multidisciplinary Coverage

British Journal of Intensive Care Evidence publishes content relevant across all medical disciplines to advance the discussion of how to generate evidence that informs patient care. Physician-scientists, trialists, and general medicine and subspecialty clinicians will all benefit from this publication.

British Journal of Intensive Care covers themes including, but not limited to:

1. Clinical Anesthesiology

• Perioperative Medicine:
• Pre-operative evaluation, risk stratification, and patient optimization.
• Enhanced Recovery After Surgery (ERAS) protocols and their implementation.
• Post-Anesthesia Care Unit (PACU) management, including handover and discharge criteria.
• General Anesthesia:
• Pharmacology, pharmacokinetics, and pharmacodynamics of intravenous and volatile anesthetic agents.
• Airway Management: techniques for routine and difficult airways, use of video laryngoscopy, supraglottic airways, and surgical airways.
• Neuromuscular blockade and reversal agents.
• Intraoperative monitoring: advanced hemodynamic monitoring, depth of anesthesia monitoring, and neuro-monitoring.
• Regional Anesthesia and Analgesia:
• Neuraxial Anesthesia: spinal, epidural, and combined spinal-epidural techniques.
• Peripheral Nerve Blocks: ultrasound-guided techniques for upper limb, lower limb, and truncal blocks.
• Continuous catheter techniques for prolonged postoperative analgesia.
• Subspecialty Anesthesia:
• Cardiothoracic Anesthesia: Management for cardiac surgery (including cardiopulmonary bypass), thoracic surgery, and use of transesophageal echocardiography (TEE).
• Neuroanesthesia: Anesthetic management for neurosurgery, neuro-radiology, and management of intracranial pressure.
• Obstetric Anesthesia: Labor analgesia, anesthesia for cesarean delivery, and management of high-risk obstetric patients.
• Pediatric Anesthesia: Anesthetic management of neonates, infants, and children, including congenital disease.
• Transplant Anesthesia: Management for solid organ transplantation (liver, kidney, heart, lung).
• Anesthesia for Ambulatory (Day-Case) Surgery and Non-Operating Room Anesthesia (NORA) for diagnostic and therapeutic procedures.

2. Intensive Care Medicine (Critical Care)

• Sepsis and Septic Shock:
• Early recognition, resuscitation bundles, and hemodynamic management.
• Pathophysiology of organ dysfunction in sepsis.
• Use of vasopressors, inotropes, and adjunctive therapies.
• Respiratory Failure and Mechanical Ventilation:
• Pathophysiology and management of Acute Respiratory Distress Syndrome (ARDS).
• Lung-protective ventilation strategies and ventilator-induced lung injury (VILI).
• Weaning from mechanical ventilation, non-invasive ventilation (NIV), and high-flow nasal cannula (HFNC).
• Hemodynamic Instability and Shock States:
• Management of cardiogenic, distributive, hypovolemic, and obstructive shock.
• Advanced hemodynamic monitoring, including cardiac output monitoring and echocardiography in the ICU.
• Neurological Critical Care:
• Management of traumatic brain injury (TBI), subarachnoid hemorrhage, ischemic stroke, and status epilepticus.
• Monitoring of intracranial pressure (ICP) and cerebral perfusion.
• Renal and Metabolic Support:
• Management of Acute Kidney Injury (AKI) in the critically ill.
• Continuous Renal Replacement Therapy (CRRT) and other forms of renal support.
• Nutritional support (enteral and parenteral) for critically ill patients.
• General Critical Care Topics:
• Sedation, analgesia, and delirium management (e.g., PADIS guidelines).
• Management of coagulopathy and thrombosis in the ICU.
• Endocrine emergencies and glycemic control.
• Post-Intensive Care Syndrome (PICS).

3. Pain Medicine

• Acute Pain Management:
• Postoperative pain control and multimodal analgesia strategies.
• Patient-Controlled Analgesia (PCA) and regional anesthesia techniques for acute pain.
• Management of acute pain in trauma and critically ill patients.
• Chronic Pain Management:
• Pathophysiology of chronic and neuropathic pain.
• Management of chronic non-cancer and cancer-related pain.
• Interventional pain procedures: nerve blocks, radiofrequency ablation, spinal cord stimulation.
• Opioid Stewardship:
• Strategies for opioid-sparing analgesia.
• Management of opioid tolerance, dependence, and addiction in the perioperative and chronic pain setting.

4. Foundational Science and Cross-Cutting Themes

• Basic and Translational Science:
• Applied physiology of the cardiovascular, respiratory, and central nervous systems.
• Pharmacology of anesthetics, analgesics, sedatives, and vasoactive drugs.
• Molecular mechanisms of anesthesia, pain, inflammation, and critical illness.
• Patient Safety, Quality Improvement, and Simulation:
• Analysis of adverse events, medical errors, and implementation of safety protocols (e.g., checklists).
• Crisis Resource Management (CRM) and teamwork training.
• Use of simulation for education, training, and credentialing.
• Resuscitation Science:
• Cardiopulmonary Resuscitation (CPR) and Advanced Cardiac Life Support (ACLS).
• Trauma resuscitation, damage control resuscitation, and massive transfusion protocols.
• Ethics and End-of-Life Care:
• Ethical dilemmas in the OR and ICU.
• Goals-of-care discussions, withdrawal of life-sustaining treatment, and organ donation after circulatory or brain death.
• Technology and Monitoring:
• Development, validation, and clinical application of new monitoring devices and technologies.
• Education and Professionalism:
• Innovations in medical education for anesthesiology and critical care trainees.
• Clinician well-being, burnout, and professional development.