Focus and Scope

American Journal of Urology Review, published by TyWin Communications. collaborates with American Medical Association are dedicated to providing physicians with the best research and important information in the world of medical research and science and to present the information in a format that is understandable and clinically useful. Committed to publishing multidisciplinary research that spans the entire spectrum of healthcare and medicine access, American Journal of Urology Review aims at an international audience of pharmacists, clinicians, medical ethicists, regulators, and researchers, providing an online forum for the rapid dissemination of recent research and perspectives in this area.

American Journal of Urology Review Evidence seeks to advance clinical trial research and clinical practice by:

• Publishing high-quality studies from the front lines of medical research.
• Challenging the medical community to take new approaches to clinical trial design and execution that yield more powerful clinical evidence.
• Sparking debate and conversation around areas of medicine where clinical decisions are made without sufficient evidence.
• Engaging physicians in a more sophisticated and meaningful way with clinical evidence.

Adhering to the rigorous peer-review and quality standards expected from American Journal of Urology Review Evidence publishes:

• Original research, clinical trials, and other clinically grounded work (e.g., epidemiology studies, first-in-human trials, meta-analyses) that validate or challenge prior clinical findings.
• Standard reviews, systematic reviews, and other review types that contextualize research findings with the aim of accelerating clinical adoption of new evidence.
• Case studies and reviews of clinical trial methodology that enhance understanding of trial strengths and weaknesses.
• Curbside consult series that addresses common patient care issues.
• Morning Report series solicited case presentation articles that are delivered in a morning report format.

Generation of Evidence

The process of generating evidence is a key area of focus for American Journal of Urology Review Evidence. We encourage readers to evaluate the reasoning behind the complex decisions that investigators make in trial design and execution, and to assess the quality of evidence produced in trials. Our goal is to build a community that takes a rigorous approach to evaluating evidence and assessing its impact on clinical decision-making.

Statistical Methods

American Journal of Urology Review Evidence guides readers toward a deeper understanding of the statistical methods used in trials. We provide concise, digestible explanations of research methods to inform the interpretation of the resulting data. In addition, we introduce readers to emerging statistical methods and types of data that will play an increasingly prominent role in future trials.

Multidisciplinary Coverage

American Journal of Urology Review Evidence publishes content relevant across all medical disciplines to advance the discussion of how to generate evidence that informs patient care. Physician-scientists, trialists, and general medicine and subspecialty clinicians will all benefit from this publication.

American Journal of Urology Review covers themes including, but not limited to:

1. Urologic Oncology

• Prostate Cancer:
• Screening, early detection (PSA, biomarkers, MRI), and risk stratification.
• Diagnosis: advanced biopsy techniques (e.g., fusion biopsy).
• Management of localized disease: active surveillance, radical prostatectomy (open, laparoscopic, robotic-assisted), radiation therapy.
• Treatment of advanced and metastatic disease: androgen deprivation therapy (ADT), chemotherapy, novel hormonal agents, immunotherapy, and targeted therapies.
• Bladder and Upper Tract Urothelial Carcinoma:
• Diagnosis and management of non-muscle invasive bladder cancer (NMIBC), including intravesical therapies (BCG, chemotherapy).
• Multimodality treatment for muscle-invasive bladder cancer (MIBC), including neoadjuvant chemotherapy and radical cystectomy with urinary diversion.
• Systemic therapies (immunotherapy, antibody-drug conjugates) for metastatic disease.
• Diagnosis and management of upper tract urothelial carcinoma (UTUC).
• Kidney Cancer (Renal Cell Carcinoma):
• Management of small renal masses.
• Surgical techniques: partial and radical nephrectomy (open, laparoscopic, robotic-assisted).
• Ablative technologies (cryoablation, radiofrequency ablation).
• Systemic therapy for advanced/metastatic disease, including targeted therapy (TKIs) and immunotherapy.
• Testicular Cancer:
• Diagnosis, staging, and management of germ cell tumors.
• Chemotherapy regimens and post-chemotherapy surgery (RPLND).
• Survivorship issues.
• Other Urologic Malignancies:
• Penile cancer, urethral cancer, and adrenal tumors.

2. Endourology, Stone Disease, and Minimally Invasive Surgery

• Nephrolithiasis (Kidney Stone Disease):
• Metabolic evaluation and medical prevention of stone formation.
• Surgical management: Extracorporeal Shock Wave Lithotripsy (ESWL), Ureteroscopy (URS) with laser lithotripsy (Holmium, Thulium), and Percutaneous Nephrolithotomy (PCNL).
• Advances in imaging and surgical technology for stone disease.
• Minimally Invasive and Robotic Surgery:
• Application of laparoscopy and robotic-assisted surgery across all urologic subspecialties (e.g., prostatectomy, nephrectomy, cystectomy, pyeloplasty).
• Comparative outcome studies, new technologies, and surgical techniques.
• Benign Prostatic Hyperplasia (BPH):
• Medical management and pharmacotherapy.
• Surgical and minimally invasive surgical therapies (MIST), including TURP, laser enucleation/vaporization (HoLEP, Greenlight), UroLift, Rezum, and others.

3. Female Urology, Voiding Dysfunction, and Neurourology

• Urinary Incontinence:
• Diagnosis and management of stress, urgency, and mixed urinary incontinence in both women and men.
• Urodynamic testing and interpretation.
• Surgical treatments (slings, artificial urinary sphincter) and non-surgical options (behavioral therapy, pelvic floor therapy, pharmacotherapy).
• Overactive Bladder (OAB):
• Pathophysiology and treatment with oral medications, Botox injections, and neuromodulation (Sacral and Tibial).
• Female Pelvic Medicine and Reconstructive Surgery (FPMRS):
• Diagnosis and management of pelvic organ prolapse (POP).
• Treatment of genitourinary fistula, urethral diverticula, and genitourinary syndrome of menopause.
• Neurourology:
• Management of lower urinary tract dysfunction resulting from neurologic conditions (e.g., spinal cord injury, multiple sclerosis, stroke, Parkinson's disease).

4. Andrology, Male Infertility, and Sexual Medicine

• Male Infertility:
• Evaluation and diagnosis of the infertile male.
• Medical and surgical management (e.g., varicocelectomy).
• Sperm retrieval techniques for assisted reproduction (MESA, TESE).
• Erectile Dysfunction (ED):
• Pathophysiology, diagnosis, and treatment with oral medications (PDE5 inhibitors), injection therapy, and vacuum devices.
• Penile prosthesis surgery.
• Male Sexual Health:
• Peyronie's disease: medical and surgical management.
• Ejaculatory and orgasmic disorders.
• Hypogonadism:
• Diagnosis and management of low testosterone, including testosterone replacement therapy (TRT).

5. Pediatric Urology

• Congenital Anomalies of the Genitourinary Tract:
• Vesicoureteral reflux (VUR), ureteropelvic junction (UPJ) obstruction, posterior urethral valves (PUV).
• Hypospadias and epispadias.
• Undescended testes (cryptorchidism) and disorders of sexual development (DSD).
• Pediatric Voiding Dysfunction and Tumors:
• Management of enuresis and other bladder control issues in children.
• Diagnosis and treatment of pediatric urologic tumors (e.g., Wilms' tumor).
• Transitional Urology:
• Managing the care of adolescents and young adults with congenital urologic conditions.

6. Reconstructive Urology

• Urethral Stricture Disease:
• Diagnosis and surgical management, including urethroplasty techniques.
• Genitourinary Trauma:
• Management of injuries to the kidney, ureter, bladder, and external genitalia.
• Urinary Tract Reconstruction:
• Upper and lower urinary tract reconstruction following trauma, surgery, or congenital conditions.

7. Basic Science, Translational Research, and Cross-Cutting Themes

• Basic Science and Pathophysiology:
• Molecular biology and genetics of urologic cancers.
• Physiology of micturition, erection, and spermatogenesis.
• Pathophysiology of stone formation and BPH.
• Translational Research:
• "Bench-to-bedside" studies, development of novel diagnostics, drugs, and medical devices.
• Urologic Imaging and Pathology:
• Advances in MRI, CT, ultrasound, and nuclear medicine for urologic diseases.
• Histopathology and molecular pathology of urologic specimens.
• Health Services Research and Health Policy:
• Studies on quality of care, patient safety, cost-effectiveness, and health disparities in urology.
• Surgical Education and Simulation:
• Innovations in training and credentialing for urologic procedures.