Focus and Scope

Nephrology, Hemodialysis and Transplantation, published by Nauchno Druzhestvo Po Nefrologiia, Khemodializa I Transplantatsiia collaborates with European Medical Association. are dedicated to providing physicians with the best research and important information in the world of medical research and science and to present the information in a format that is understandable and clinically useful. Committed to publishing multidisciplinary research that spans the entire spectrum of healthcare and medicine access, Nephrology, Hemodialysis and Transplantation aims at an international audience of pharmacists, clinicians, medical ethicists, regulators, and researchers, providing an online forum for the rapid dissemination of recent research and perspectives in this area.

Nephrology, Hemodialysis and Transplantation Evidence seeks to advance clinical trial research and clinical practice by:

• Publishing high-quality studies from the front lines of medical research.
• Challenging the medical community to take new approaches to clinical trial design and execution that yield more powerful clinical evidence.
• Sparking debate and conversation around areas of medicine where clinical decisions are made without sufficient evidence.
• Engaging physicians in a more sophisticated and meaningful way with clinical evidence.

Adhering to the rigorous peer-review and quality standards expected from Nephrology, Hemodialysis and Transplantation Evidence publishes:

• Original research, clinical trials, and other clinically grounded work (e.g., epidemiology studies, first-in-human trials, meta-analyses) that validate or challenge prior clinical findings.
• Standard reviews, systematic reviews, and other review types that contextualize research findings with the aim of accelerating clinical adoption of new evidence.
• Case studies and reviews of clinical trial methodology that enhance understanding of trial strengths and weaknesses.
• Curbside consult series that addresses common patient care issues.
• Morning Report series solicited case presentation articles that are delivered in a morning report format.

Generation of Evidence

The process of generating evidence is a key area of focus for Nephrology, Hemodialysis and Transplantation Evidence. We encourage readers to evaluate the reasoning behind the complex decisions that investigators make in trial design and execution, and to assess the quality of evidence produced in trials. Our goal is to build a community that takes a rigorous approach to evaluating evidence and assessing its impact on clinical decision-making.

Statistical Methods

Nephrology, Hemodialysis and Transplantation Evidence guides readers toward a deeper understanding of the statistical methods used in trials. We provide concise, digestible explanations of research methods to inform the interpretation of the resulting data. In addition, we introduce readers to emerging statistical methods and types of data that will play an increasingly prominent role in future trials.

Multidisciplinary Coverage

Nephrology, Hemodialysis and Transplantation Evidence publishes content relevant across all medical disciplines to advance the discussion of how to generate evidence that informs patient care. Physician-scientists, trialists, and general medicine and subspecialty clinicians will all benefit from this publication.

Nephrology, Hemodialysis and Transplantation covers themes including, but not limited to:

I. General and Clinical Nephrology

• Acute Kidney Injury (AKI):
  • Pathophysiology, etiology, and risk stratification.
  • Novel biomarkers for early detection and prognosis.
  • Management strategies in different clinical settings (e.g., ICU, post-surgery).
  • Outcomes, including progression to chronic kidney disease.
• Chronic Kidney Disease (CKD):
  • Epidemiology, progression factors, and public health initiatives.
  • Management of complications: anemia, mineral and bone disorders (CKD-MBD), cardiovascular disease.
  • Slowing progression: pharmacological and lifestyle interventions.
  • Patient-centered care, symptom management, and quality of life.
• Glomerular and Tubulointerstitial Diseases:
  • Pathogenesis and treatment of primary and secondary glomerulonephritis (e.g., IgA nephropathy, lupus nephritis, membranous nephropathy).
  • Nephrotic and nephritic syndromes.
  • Acute and chronic interstitial nephritis, including drug-induced nephrotoxicity.
• Hypertension and the Kidney:
  • Pathophysiology of renovascular and primary hypertension.
  • Resistant hypertension: diagnosis and management.
  • Blood pressure targets and management in patients with CKD and post-transplantation.
• Genetic and Congenital Kidney Diseases:
  • Polycystic kidney disease (ADPKD, ARPKD) and other ciliopathies.
  • Alport syndrome and other hereditary nephritis.
  • Congenital anomalies of the kidney and urinary tract (CAKUT).
• Fluid, Electrolyte, and Acid-Base Disorders:
  • Complex and challenging cases of hyponatremia, hypernatremia, and potassium disorders.
  • Simple and mixed acid-base disturbances.
• Specialty Areas in Nephrology:
  • Onconephrology: Kidney-related complications of cancer and cancer therapies.
  • Cardiorenal Syndrome: Pathophysiological links and management of combined heart and kidney failure.
  • Geriatric Nephrology: Management of kidney disease in the elderly, including decision-making about dialysis.
  • Pediatric Nephrology: Diagnosis and management of kidney diseases in children.

II. Hemodialysis and Renal Replacement Therapy

• Hemodialysis (HD):
  • Vascular Access: Creation, maturation, surveillance, and management of arteriovenous fistulas (AVF), grafts (AVG), and central venous catheters (CVC); management of access complications.
  • Dialysis Adequacy and Prescription: Kt/V, high-flux and high-efficiency dialysis, incremental and frequent dialysis schedules.
  • Technology and Techniques: Dialyzer membranes, dialysate composition, online hemodiafiltration (HDF), sorbent-based technologies.
  • Intradialytic Complications: Hypotension, cramps, hemodynamic instability, and their management.
  • Long-Term Complications: Dialysis-related amyloidosis, cardiovascular morbidity, nutritional issues.
• Peritoneal Dialysis (PD):
  • Catheter insertion and care.
  • PD prescription: automated peritoneal dialysis (APD) and continuous ambulatory peritoneal dialysis (CAPD).
  • Management of peritonitis and exit-site infections.
  • Membrane biology, transport characteristics, and technique survival.
• Continuous Renal Replacement Therapy (CRRT):
  • Application in critically ill patients with AKI and multi-organ failure.
  • Modality selection (CVVH, CVVHD, CVVHDF), anticoagulation, and dosing.
• Home and Innovative Dialysis Modalities:
  • Studies on home hemodialysis (HHD) and wearable/implantable artificial kidneys.
  • Training, support, and outcomes for home dialysis patients.
• Quality of Life and Palliative Care:
  • Patient-reported outcomes (PROs) in the dialysis population.
  • Conservative kidney management and palliative/supportive care for end-stage kidney disease.

III. Kidney Transplantation

• Pre-Transplant Evaluation and Waitlist Management:
  • Recipient selection criteria and management of comorbidities.
  • Immunological assessment: HLA typing, crossmatching, and panel reactive antibody (PRA) analysis.
  • Living and deceased donor evaluation and selection.
• Immunosuppression:
  • Induction and maintenance therapy protocols.
  • Clinical trials of novel immunosuppressive agents.
  • Minimization, withdrawal, and personalization of immunosuppression.
  • Management of side effects (e.g., nephrotoxicity, new-onset diabetes after transplantation).
• Rejection:
  • Diagnosis and management of acute and chronic T-cell mediated and antibody-mediated rejection (AMR).
  • Non-invasive monitoring for rejection (e.g., donor-derived cell-free DNA).
  • Pathology of transplant rejection.
• Post-Transplant Complications and Long-Term Management:
  • Infectious complications (CMV, BKV, fungal infections).
  • Cardiovascular disease, hypertension, and dyslipidemia post-transplant.
  • Post-transplant malignancy.
  • Recurrence of original kidney disease in the allograft.
• Surgical and Allograft-related Issues:
  • Surgical techniques and their outcomes.
  • Management of early and late surgical complications (e.g., urinary leaks, lymphoceles).
  • Long-term allograft survival and factors influencing graft loss.

IV. Foundational and Cross-Cutting Themes

• Renal Pathology:
  • Light microscopy, immunofluorescence, and electron microscopy findings in native and transplant kidney biopsies.
  • Correlation of pathology with clinical outcomes.
• Basic Science and Translational Research:
  • Molecular mechanisms of fibrosis, inflammation, and cell injury in the kidney.
  • Genetics and genomics of kidney disease.
• Epidemiology and Health Economics:
  • Population-based studies on the burden of kidney disease.
  • Cost-effectiveness analyses of therapies in nephrology, dialysis, and transplantation.
• Diagnostics and Imaging:
  • Advances in renal imaging (ultrasound, MRI, CT).
  • Nuclear medicine in nephrology and transplantation.