Molluscum Contagiosum: Cantharidin vs. Cryotherapy in Children
Keywords:
Molluscum contagiosum; cantharidin; cryotherapy; pediatric dermatology; pain.Abstract
Introduction: Molluscum contagiosum is common in children, but treatment can be painful. This review compares efficacy and tolerability of cantharidin 0.7% topical vs. cryotherapy. Methods: Five RCTs (n=462 children, age 2–12 years). Primary outcome: complete clearance at 4 weeks after up to 3 treatments. Secondary: pain score (0-10). Results: Cantharidin achieved 81% clearance vs 74% for cryotherapy (p=0.09). Mean pain score: cantharidin 1.2 vs cryotherapy 5.8 (p<0.001). Blistering occurred in 32% with cantharidin (mostly mild). Cryotherapy caused hypopigmentation in 14%. Discussion: Cantharidin causes blister formation without immediate pain, improving adherence. Studies were unblinded due to treatment nature. Conclusions: Cantharidin is as effective as cryotherapy with superior tolerability, making it first-line for pediatric molluscum.
